Necroptosis: Molecular Signalling and Translational Implications

Necroptosis: Molecular Signalling and Translational Implications

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Necroptosis is a form of programmed necrosis whose molecular players are partially awid sr-2400 shared with apoptotic cell death.Here we summarize what is known about molecular signalling of necroptosis, particularly amrutharishtam price focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance.We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.